Pacific Northwest Research Institute

Pacific Northwest Research Institute (PNRI) is seeking an experienced EHS and Biosafety Officer to join our team. The EHS and Biosafety Officer is responsible for managing all PNRI Health and Safety programs, including radiation safety, hazardous waste management and disposal, spill response, animal safety, and workplace safety. The EHS and Biosafety Officer provides active support to PNRI’s IBC and IACUC. Working closely with building Facilities, the EHS and Biosafety Officer assures compliance with WISHA, OSHA, DOT, and all relevant regulations.  Reporting to the Chief Financial & Administrative Officer, this critical role proactively identifies and mitigates health and safety risks within PNRI and ensures compliance with all local, state, and federal regulations, including maintaining all registrations, licenses, and permits concerning the environmental health and safety of the Institute.  The successful candidate will demonstrate a thorough knowledge of laboratory research safety processes and procedures, as well as relevant workplace regulatory requirements. Leveraging their subject matter expertise and knowledge of laboratory safety and risks, the EHS and Biosafety Officer has primary responsibility for the Health and Safety function at PNRI and operates with a high level of autonomy and authority.   Why PNRI? PNRI is an independent, nonprofit, biomedical research institute with a distinguished history of contributing scientific advances to improve health. We believe genetic research holds untapped potential to improve human health. PNRI pursues an unanswered question in the field of genetics: what keeps people healthy in the face of genetic and environmental risk?  At PNRI, our culture encourages originality, risk-taking, and interdisciplinary collaboration.   What you will do: To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.   Policy Establishment Creates, maintains and updates PNRI Health & Safety Manual and intranet. Creates, maintains and updates monitoring and response programs to ensure compliance with exposure limits for hazardous chemicals and radioactive materials. Develops, facilitates and tracks new employee training and annual safety training for all staff, including but not limited to radiation, bloodborne pathogens, and laboratory safety, in conjunction with Human Resources.  Radiation Protection, Biological & Chemical Programs Ensures compliance with “cradle to grave” chemical and radioactive tracking, dosimetry, and disposal requirements in coordination with Facilities department. Maintains radioactive materials database. Maintains chemical inventory systems. Manages the transfer of all biological agents entering and leaving PNRI. Research Support Programs Ensures PNRI’s animal facilities are in compliance with applicable regulations, statutes, and PNRI policies in coordination with IACUC and Facilities; serves as a member of the IACUC. Ensures PNRI’s use of biological agents are in compliance with applicable regulations, statutes, and PNRI policies in coordination with IBC and Facilities; serves as a member of the IBC. Compliance/Enforcement Ensures compliance with sewer disposal guidelines. Ensures compliance with Material Safety Data Sheet (MSDS) and Federal “Right to Know” requirements. Works closely with Operations and Human Resources staff to ensure a safe working environment for all staff. Chairs Health & Safety, Biosafety, and IACUC Committees including attending meetings and maintaining meeting minutes Maintains Health & Safety bulletin board with all required postings. Manages weekly wipe test program and monthly laboratory safety inspections and tracks results in database.   What you bring: To perform this job successfully, an individual should be able to demonstrate the requirements listed below which are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Education and Experience Bachelor's Degree in a related field such as Biology, Microbiology, Industrial Hygiene or equivalent in years of experience and education. Occupational Safety and Health degree, a plus. Minimum of two years’ working experience in a laboratory, required; or the equivalent experience, training & mentorship. Five years’ experience managing health and safety programs in a laboratory research environment, highly preferred. Minimum of three years' experience of direct oversight/management of health and safety programs in a laboratory research environment, required. Demonstrated knowledge of federal, state, & local regulatory requirements and EHS and Biosafety policies, procedures and programs required; animal health experience and knowledge of OLAW requirements, a plus. Professional EHS certifications (ASP, CSP, CIH, CHMM, QEP, CEA, REM, etc.) desired. Previous successful experience as a member of an Institutional Review Board (IRB) highly preferred. Radiation, Chemical Hygiene and Hazardous Waste Operations certification, preferred.  Skills and Abilities   Demonstrated ability to proactively identify and solve potential risks. Demonstrable success managing multiple priorities and processes simultaneously. Verified time management skills and the ability to meet deadlines. Proven intermediate+ knowledge of Microsoft Office (i.e., Excel) required. Demonstrable written and verbal communication skills to effectively communicate with a wide range of stakeholders, including scientists. Established and verified track record of a high level of attention to detail and a high degree of accuracy. Confirmable self-starter with successful independent and efficient work performance. Demonstrated ability to work as a collaborative team player, across diverse teams.   PNRI is committed to creating a diverse environment and all qualified candidates are encouraged to apply .   How to Apply: Want to be a part of the team at PNRI?  Please click on the link to submit your application today! The annual base salary for this position is from $100,000 to $125,000 and the wage offered will be based on experience and qualifications. PNRI requires vaccination for COVID 19 as a condition of employment. Please see www.pnri.org for more information.     PNRI is an equal opportunity employer.  PNRI does not, and will not, discriminate against any applicant or employee on the basis of race, creed, ancestry, color, religion, sex, gender, gender identity/expression, sexual orientation, national origin, citizenship status, mental or physical disability, age, genetic information, veteran status, marital or family status, family or medical care leave, pregnancy or related condition (including childbirth and/or nursing), political affiliation or any other characteristic protected by state or federal law or local ordinance.  We believe diversity, equity, inclusion, and belonging is not only good business, it’s the right thing to do.

PNRI is looking for a top-notch Grants Manager to partner and collaborate with the Principal Investigators (PI’s) in the holistic governance of all grants pre- and post-award management. This critical position is accountable for the submission, oversight, reporting, compliance, and relationship management for a portfolio of PNRI’s grants. The Grants Manager is responsible for researching, preparing, submitting, and managing grant proposals/reports which support PNRI’s goals. This position requires strong writing, communication, budget review, and time and project management skills, with an emphasis on outcome measurement. This position will serve as a liaison between the PI’s and the Finance and Administrative staff. Demonstrated problem solving skills are critical to success, as well as taking initiative and ownership over the role and responsibilities. The successful candidate will be detail oriented, well- organized, and a team player with a high level of work integrity and ethical standards.   Why PNRI? Not only do we have a long and distinguished history, but we are also a relevant part of the future in genetic research. Our institute offers a diversity in science; and continues to expand. Our PI’s are committed to finding opportunities for their labs to collaborate in their pursuit of genetic research to improve human health. PNRI is building a team and a community dedicated to contributing scientific advances to improve the health of all people.   What you will do: To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.   Pre-Award Responsibilities   Lead grant proposal development and submission—preparing and organizing materials for research proposals, contracts, sub-contracts, agreements, and submitting and monitoring grant application. Read and understand grant proposal requirements and develop plan for proposal completion, including systematically collecting components (e.g., biosketches, letters of support, facilities descriptions, personnel information); establishing timelines; creating/maintaining collaborative workspaces; and acting as PNRI authorized official, submitting proposal to funding agency. Maintain and build relationships with funders and other strategic Analyze and evaluate contract and grant budgets for correct calculation and allowability of expenditure categories such as salaries, percent of effort, salary adjustment increases, fringe benefits, indirect costs, materials, and Coordinate just-in-time response, collecting and reviewing any documents requested by funding agency. Maintains proposal and funding Post-Award Responsibilities   Analyze and evaluate awarded proposals, contracts, and subcontracts for compliance with funding agency, federal, state, and Institute requirements; prepares required acceptance documentation, recommends approval or rejection of deviations from contract specifications. Perform budget evaluation confirming calculations and allowability of Maintain grant compliance and reporting, including outcome measurement and grant budgets—taking responsibility for meeting high standards of effectiveness, timeliness, and completeness. Negotiate and execute all ancillary agreements under sponsored These include but are not limited to subcontracts, consulting agreements, and service agreements. Maintain master calendar of grants and prospects and all associated files and Maintain library of grant support documents including resumes, bio-sketches, other support documents, etc. Coordinate all grant closeout activities, working with PI and grants accountant to ensure all reporting requirements are met. What you bring: To perform this job successfully, an individual should be able to demonstrate the requirements listed below which are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Bachelor’s degree or equivalent experience and/or Three years of NIH and/or NSF grant management experience with human subject component required. Validated experience with budgets, progress reporting and other compliance requirements for multiple award types including federal grants. Demonstrated administrative skills and self-motivated with the ability to set priorities, manage deadlines, problem solve, and manage multiple tasks under minimal supervision in an effective and efficient manner, without a reduction in quality or customer satisfaction. Verifiable, collaborative team player with a demonstrated track record of partnering, relationship building, and customer service skills. Intermediate to expert skills in Microsoft Office (specifically Word, Excel and PowerPoint) required. Experience with donor development/CRM software systems a plus. Experience in a nonprofit environment a Experience with Intacct software PNRI is committed to creating a diverse environment and all qualified candidates are encouraged to apply. How to apply: Want to be a part of the team PNRI? Please click on the link to submit your application today. The annual base salary for this position is from $91,000 to $127,000 and the wage offered will be based on experience and qualifications. PNRI requires vaccination for COVID 19 as a condition of employment. Please see www.pnri.org for more information. About PNRI: PNRI is an independent, nonprofit, biomedical research institute with a distinguished history of contributing scientific advances to improve health. We believe genetic research holds untapped potential to improve human health. PNRI pursues an unanswered question in the field of genetics: what keeps people healthy in the face of genetic and environmental risk? At PNRI, our culture encourages originality, risk-taking, and interdisciplinary collaboration.   PNRI is an equal opportunity employer. PNRI does not, and will not, discriminate against any applicant or employee on the basis of race, creed, ancestry, color, religion, sex, gender, gender identity/expression, sexual orientation, national origin, citizenship status, mental or physical disability, age, genetic information, veteran status, marital or family status, family or medical care leave, pregnancy or related condition (including childbirth and/or nursing), political affiliation or any other characteristic protected by state or federal law or local ordinance. We believe diversity, equity, inclusion, and belonging is not only good business, it’s the right thing to do.

The Carvalho Laboratory (https://pnri.org/carvalho-lab/) at the Pacific Northwest Research Institute (PNRI) in Seattle, WA seeks a proactive and goal-oriented Postdoctoral Fellow who is passionate about genetics and the molecular basis of rare human genetic diseases. The successful candidate will be participating in several collaborative (multi-lab) projects to investigate the structure and molecular mechanisms underlying formation of structural variation in patients and family members with rare genetic diseases.   Research in the Carvalho Lab aims to investigate the mechanism of formation of de novo variants in the human genome and how they contribute to disease using a wide range of bioinformatic tools and NGS methodologies (please see our publications here https://scholar.google.com/citations?hl=en&user=JvZz2rUAAAAJ ).The successful candidate will generate and analyze molecular and computational data from genome (Nanopore, PacBio), methylome and transcriptome from long-read sequencing in addition to investigate ultra-high molecular weight DNA using optical genome mapping. The ideal candidate will develop experiments involving human tissue culture growth and maintenance including lymphoblastoid cell lines and skin fibroblasts, conduct molecular experiments such as quantitative PCR, preparation and analysis of RNA, preparation and quality control of libraries for sequencing, and statistical analysis and summaries of data for publication. The Postdoctoral Fellow will be strongly encouraged to write manuscripts and grants as well as participate in scientific national and international conferences.   The highly collaborative, interdisciplinary nature of our laboratory provides a strong training environment in the areas of human genetics and genomics, as well as the opportunity to collaborate with world experts in the field of rare diseases and structural variation. The Carvalho Lab and the broader PNRI community actively strive to increase diversity in STEM, translate our discoveries in ways that benefit society, and train the next generation of scientists.   What you will do: To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.   Design, develop, implement, and execute scientific research under supervision of Principal Investigator. Perform periodical/literature searches in preparation for study design. Maintain substantial knowledge of current scientific and theories. Prepare laboratory equipment and resources. Conduct research, monitor experiments, make observations, and perform hands on observations and activities. Participate in analysis and interpretation of study data. Contribute to scientific literature, grant writing, and conferences in conjunction with Principal Scientist. May develop and implement methodologies, instrumentation, and procedures. May mentor undergraduate and graduate students. What you bring: To perform this job successfully, an individual should be able to demonstrate the requirements listed below which are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.   Doctoral degree (PhD, MD, or equivalent) required. Prior experience in a research environment required. Demonstrated knowledge and expertise in genetics and basic molecular technologies required. Verified training and experience with human tissue culture growth and maintenance desired. Proven ability in computational methods and tools for using short and long-read, next-generation sequencing to study the human genome a plus. Demonstrated motivation and ability for applying new technologies to exciting research questions. Demonstrable written and verbal communication skills and the proven ability to thrive in a team environment and work collaboratively as well as independently. Track record of publication in peer-reviewed journals.     PNRI is committed to creating a diverse environment and all qualified candidates are encouraged to apply.     How to apply: The annual base salary for this position is from $69,264.00 to $73,075.00 and the wage offered will be based on experience, qualifications and the NRSA stipend level. PNRI requires vaccination for COVID 19 as a condition of employment. Please see www.pnri.org for more information. To apply, please click on the link to visit our site to complete and submit your application today.   PNRI is an equal opportunity employer.  PNRI does not, and will not, discriminate against any applicant or employee on the basis of race, creed, ancestry, color, religion, sex, gender, gender identity/expression, sexual orientation, national origin, citizenship status, mental or physical disability, age, genetic information, veteran status, marital or family status, family or medical care leave, pregnancy or related condition (including childbirth and/or nursing), political affiliation or any other characteristic protected by state or federal law or local ordinance.  We believe diversity, equity, inclusion, and belonging is not only good business, it’s the right thing to do.      

Office Manager PNRI is looking for an Office Manager to lead a variety of functions that are foundational to creating a welcoming, inclusive, and well-organized office experience for PNRI staff and visitors. This highly visible position develops, implements, manages, and maintains the processes that support the institute’s office operations.  The Office Manager is responsible for oversight of day-to-day office activities ensuring efficiency through the design and implementation of office policies, standards, and procedures. The successful candidate will have a minimum of three years of successful experience in office management and at least two years of experience directly managing direct reports.  This position requires strong writing, communication skills, budget review & management success, as well as demonstrated detail orientation, collaboration, and project management skills, with an emphasis on outcome measurement. The successful candidate and their team will support the Board of Trustees, senior leadership, and scientific faculty. Demonstrated problem solving skills are critical to success, as well as taking initiative and ownership over the role and responsibilities. The successful candidate will have a verifiable track record maintaining confidentiality of sensitive data, is well-organized, and a team player with a high level of work integrity and ethical standards.   Why PNRI? Not only do we have a long and distinguished history, but we are also a relevant part of the future in genetic research.  Our institute offers a diversity in science; and continues to expand. Our PI’s are committed to finding opportunities for their labs to collaborate in their pursuit of genetic research to improve human health.  PNRI is building a team and a community dedicated to contributing scientific advances to improve the health of all people.   What you will do: To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.   Design and implement office policies by establishing standards and procedures, measuring results against standards, and making necessary adjustments. Ensure office efficiency by assigning & monitoring clerical/administrative functions including but not limited to maintaining common areas, handling correspondence, managing file systems, and overseeing supplies and equipment. Oversee day-to-day office activities including reception and keep management informed regularly via performance reports. Achieve financial objectives through effective management of the office G&A budget, scheduling expenditures, analyzing variances, inventory, schedule, and source general office and F&B supplies, and supervise budget purchasing from PO to reconciliation, and ensuring accurate & timely reporting. Provide direct administrative support as needed, including scheduling appointments, meetings & events, booking travel, mailing & shipping packages, and updating contacts database & employee directories. Execute, oversee, and become the point of historical reference for the business services document management system, including defining procedures for the retention, protection, retrieval, transfer, and disposal of records, as assigned. Oversee and maintain office equipment for uninterrupted function, identify needs and acquire supplies, manage vendor relationships, coordinate food deliveries when requested and manage contract & price negotiations with office vendors, as assigned. Partner with the Director of Operations in the management of space/infrastructure planning (i.e., moves, additions, changes to workstations), office condition maintenance, and provide answers, resources, and solutions when requested for office management issues (e.g., stationery and business cards). Partner with HR to update and maintain office policies as necessary. Assist in the onboarding process for new hires. Plan in-house or off-site activities, like employee events, conferences, and Board of Trustees meetings. Provide administrative support to the Board of Trustees, senior leadership, and scientific faculty, including, but not limited to, professionally and discretely managing correspondence, calendars, directories, databases, and files, scheduling meetings, and recording meeting minutes, as well as compiling, organizing, and editing documents and reports, as directed. Handle enquiries and requests and act as the administrative point of contact between executives and internal/external clients. Manage and develop admin/clerical staff (i.e., Front Office Coordinator) through recruiting, selecting, orienting, training, , coaching, counseling & disciplining employees, and planning, monitoring & appraising job results while ensuring senior management receives regular team activity and performance reports. Oversee the day-to-day activities performed by the admin/clerical team and ensure staff accurately report work and PTO hours and receive coverage for rest and meal breaks. Ensure office efficiency by performing and assigning admin/clerical functions, including, but not limited to maintaining and monitoring communal areas. Ensure adherence to business services policies and procedures and work jointly with senior management in the development and implementation of adjustments and new standards.   What you bring: To perform this job successfully, an individual should be able to demonstrate the requirements listed below which are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.   High School Diploma or equivalent; Bachelor’s degree a plus. A minimum of three (3) years of successful experience in office management; previous experience with a research institute or non-profit organization desired. A minimum of two (2) years of experience directly managing/overseeing employees required. CAP, PACE, CBOM or Office Manager Certification from NACPB a plus. Demonstrable written and verbal communication skills to effectively and professionally communicate and collaborate with a wide range of stakeholders, including scientists, Board of Trustees members, and executive leadership. Proven ability to thrive in a team environment and work collaboratively. Established and verified track record of a high level of attention to detail, a high degree of accuracy and timely follow-through. Demonstrated ability to work independently and a track record of success with multi-tasking, goal setting, and workload prioritization. Proven intermediate+ knowledge of Microsoft Office, SharePoint, Canva, office machines (i.e., copiers and postage machines) and meeting scheduling tools (i.e., Outlook, Zoom, Bookings and/or Calendly). Demonstrated ability to maintain confidentiality of sensitive data, information and files including, but not limited to, Board of Trustees information. Established and verified success with navigating change and adjusting to new tasks, procedures, or policies as office needs change. Experience in a nonprofit environment a Experience with Intacct software   PNRI is committed to creating a diverse environment and all qualified candidates are encouraged to apply. How to apply: Want to be a part of the team at PNRI? Please complete and submit the application form on our website. The annual base salary for this position is from $55,000 to $70,000 and the wage offered will be based on experience and qualifications. PNRI requires vaccination for COVID 19 as a condition of employment. Please see www.pnri.org for more information.     About PNRI: PNRI is an independent, nonprofit, biomedical research institute with a distinguished history of contributing scientific advances to improve health. We believe genetic research holds untapped potential to improve human health. PNRI pursues an unanswered question in the field of genetics: what keeps people healthy in the face of genetic and environmental risk? At PNRI, our culture encourages originality, risk-taking, and interdisciplinary collaboration.   PNRI is an equal opportunity employer. PNRI does not, and will not, discriminate against any applicant or employee on the basis of race, creed, ancestry, color, religion, sex, gender, gender identity/expression, sexual orientation, national origin, citizenship status, mental or physical disability, age, genetic information, veteran status, marital or family status, family or medical care leave, pregnancy or related condition (including childbirth and/or nursing), political affiliation or any other characteristic protected by state or federal law or local ordinance. We believe diversity, equity, inclusion, and belonging is not only good business, it’s the right thing to do.

The Pacific Northwest Research Institute (PNRI) Summer Undergraduate Research Internship (SURI) is a research-intensive, nine-week program for undergraduate students who have an interest in pursuing a career in the biomedical sciences and who have completed at least one year of study at a university or college. Interns will work on a research project within the laboratory of their primary mentor and will present their work as a short talk at our annual Intern Research Symposium. As a group, the interns will participate in additional scientific, career development, and social activities. PNRI labs host interns through partnerships with universities and local nonprofit organizations, like  Rainier Scholars . We are honored to play a role in building the career of future scientists. Students who identify as African American, Hispanic, Native American, Southeast Asian, Native Alaskan or Native Pacific Islander or another group historically excluded from the sciences OR who are from low-income homes OR who are the first in their family to attend college OR who attend two-year colleges or small liberal arts institutions without broad research facilities are strongly encouraged to apply. PNRI labs hosting interns this summer: The Carvalho Lab  applies state-of-the-art molecular sequencing technologies to investigate the genome of individuals with rare diseases. Our goal is to investigate disease-specific genomic alterations to understand how they contribute to disease expression and the mechanisms underlying DNA variation formation. Students will learn human genetics and analysis of next-generation sequencing data in the context of diseases. Potential projects will allow interns to learn and use various technologies and methodologies to study the structure of the genome.   The Dudley Lab  studies how naturally occurring genetic variation leads to the stunning array of phenotypic diversity that we see on the planet. As an undergraduate intern in our lab, you will use a combination of classic microbiology, modern genomics, and high throughput robotics to discover which mutations in human genes could cause disease. Potential projects will focus on genes that cause rare childhood diseases in which rapid diagnosis can positively impact a patient's health outcome.   The McLaughlin Lab  studies genome evolution with a particular interest in the evolutionary arms race between our genomes and pathogens like viruses and transposons. As an undergraduate intern in our lab, you will use a combination of molecular and computational biology to explore how our innate immune genes evolve to stop pathogens and the diseases that result when our immune system falters. Potential projects will focus on studying new genes that contribute to our ability to prevent disease and how pathogen replication could drive autoimmune disease.   The Metzger Lab  studies a transmissible cancer in clams in which the cancer cells themselves jump from animal to animal through the environment. As an undergraduate intern in our lab, you will use a combination of experimental and computational techniques to grow clam cancer cells in the lab, analyze cancer genomes, and detect cancer-specific DNA in seawater. Potential projects will focus on understanding how cancer can evolve and how host animals can become resistant to it.   The Stubbs Lab  studies the genetics of brain development, and how differences in brain development translate into individual behaviors and susceptibility/resilience to disease. As an undergraduate intern in our lab, you will study genes encoding regulatory factors—transcription factors and key signaling molecules—that sit atop gene networks that are activated with precise timing and sequence to build and maintain a fully functioning brain. Potential projects will include studying genes that function in the brain to impact social interactions, emotions, and intellectual capabilities.    By participating in this internship, you will: Conduct scientific research in a biomedical research lab Participate in scientific seminars, journal clubs, and career development activities Interact with scientists from a variety of different disciplines, including genetics, evolutionary biology, biomedical engineering, medicine, and computational biology Learn about a wide range of career options in the fields of life science research, industry, and medicine Present the results of your research to your peers and colleagues   Qualifications: Must be a current college student, entering their second or later year in 2024. Must have a strong interest in life sciences, medicine, math, or engineering Must be able to commit 30 hours per week for a minimum of nine (9) consecutive weeks between Monday, June 10 and Friday, August 30, 2024. Specific dates will be determined with consideration to each student’s academic calendar and their host lab’s availability   How to apply: Applications are accepted from  December 4, 2023 to February 23, 2024  and will be reviewed upon receipt, with interviews conducted (via Zoom) in early March 2024. We encourage applicants to review our “Tips for Submitting a Quality Application” below. Interns will receive a stipend of $5,600.00 paid on a monthly schedule of $1,400.00 per payment. The length of the SURI program shall last nine weeks.  SURI Interns are expected to commit at least 30 hours of work per week to the program. Interns are responsible for all costs associated with their travel to Seattle, local housing for the duration of the program, and meals. PNRI will provide a free ORCA card for local public transportation to each intern. Housing is available through the  University of Washington’s Seattle Intern Housing Program  and may be available through  Seattle University .   Tips for submitting a quality application: The SURI is a competitive program. While adhering to the following recommendations does not guarantee acceptance into the program, it does improve your chances of creating a successful application. Review PNRI hosting lab information to identify faculty whose research is of interest to you. Give yourself adequate time to prepare a thoughtful, detailed application. Relevant information includes but is not limited to explaining: In which hosting lab would you be interested in gaining research experience and why. How the focus of the lab relates to your research interests (e.g., classic microbiology, modern genomics, transmissible cancer, high throughput robotics, and/or analysis of next-generation sequencing data). How the SURI opportunity may further your academic and career goals. Before submitting your application: Proofread your application materials by thoroughly reviewing your responses and supporting materials for accuracy and completeness. Given the number of applications received and in fairness to other applicants, the program is unable to accept late or revised materials. Ask others to review your application materials. Ask friends, professors, or faculty advisors to review your statement and provide suggestions for your consideration. Coming soon: Please join us in January for an information session about projects you could work on as an intern at PNRI and a workshop on how to write a cover letter and résumé for a research internship. Check back soon for date, time, and registration information.   How to apply: To apply, please click the link below to complete and submit the application form  and  include the following items: Résumé, which should include a brief description of the science, math, and computer science classes you have taken One-page statement describing 1) how participation in the internship will enhance your education and career goals; 2) which lab(s) most interest(s) you and why   https://pnri.org/careers/2024-suri/    If you have questions, please email us at  suri@pnri.org .   About PNRI:   PNRI is an independent, nonprofit, biomedical research institute with a distinguished history of contributing scientific advances to improve health. We believe genetic research holds untapped potential to improve human health. PNRI pursues an unanswered question in the field of genetics: what keeps people healthy in the face of genetic and environmental risk?  At PNRI, our culture encourages originality, risk-taking, and interdisciplinary collaboration.  PNRI is an equal opportunity employer.  PNRI does not, and will not, discriminate against any applicant or employee on the basis of race, creed, ancestry, color, religion, sex, gender, gender identity/expression, sexual orientation, national origin, citizenship status, mental or physical disability, age, genetic information, veteran status, marital or family status, family or medical care leave, pregnancy or related condition (including childbirth and/or nursing), political affiliation or any other characteristic protected by state or federal law or local ordinance.  We believe diversity, equity, inclusion, and belonging is not only good business, it’s the right thing to do.  

PNRI is recruiting a Staff Scientist to play a key leadership role in the Decoding Stress project based in the Stubbs Lab.  This project, initiated as a collaboration that integrated novel computational methods developed by Dr. David Galas and basic science mechanistic studies in the Stubbs group, is focused on uncovering the genetic mechanisms of stress-related health disorders with particular focus on how brain stress responses may contribute to comorbid disorders of metabolic and mental health.  The project aims to identify genetic alleles associated with disease susceptibility or resilience in clinical populations, including the search for genetic modifiers that can alter the effects of the primary alleles. Novel candidate genes and interactions will then be validated in mouse models, with mechanistic and functional insights developed at the genetic, genomic, cellular, and molecular levels. Ultimately, the project will identify novel loci and molecular pathways that can be used as translational targets for improving diagnostic applications or therapeutic outcomes in humans.      The ideal candidate will have a vision for helping build a new multidisciplinary program leveraging insights from basic science and computational biology for the development of real world clinical/translational impact. We seek a highly motivated, energetic individual who can bring additional expertise in human genetics/clinical genetics, stress biology, and translational research methods into the team. The Staff Scientist will use their knowledge of human genetics and stress biology to help guide the identification of genes and gene networks in collaboration with the other team members.  The Staff Scientist will also lay the foundation for future clinical work by establishing external relationships with potential collaborators that have access to relevant clinical populations.  As a member of the project team, the Staff Scientist will actively contribute to scientific publications and the pursuit of funding opportunities.  For early career candidates, this is an opportunity for mentorship in scientific leadership and project management skills in a supportive, collaborative, and flexible professional environment.   What you will do:   To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Design, develop, implement, and execute scientific research for the Decoding Stress study under supervision of the Principal Investigator. In collaboration with the Principal Investigator, lay the foundation for future clinical work by establishing external relationships with potential collaborators with access to relevant clinical populations. Contribute to scientific publications, conferences, and the pursuit of funding opportunities. Maintain substantial knowledge of current scientific principles and theories relevant to the Decoding Stress project. Perform periodical/literature searches in preparation for study design. Participate in the analysis and interpretation of study data. Develop and implement research methodologies, instrumentation, and procedures. May coordinate activities of staff engaged on the Decoding Stress   What you bring:   To perform this job successfully, an individual should be able to demonstrate the requirements listed below which are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Doctoral degree (Ph.D., M.D. or equivalent) with post-graduate work experience relevant to the aims of the Decoding Stress project is required. Demonstrated knowledge of and experience in the analysis and interpretation of GWAS data, including the use of relevant computational tools. Verified training and expertise in the biology of stress response, including genetic, endocrinological and neurological systems. Proven knowledge of stress-related metabolic disorders and/or mental health effects in humans. Confirmable experience identifying and developing new collaborations with basic science and clinical contacts to advance research goals. Demonstrated high level of commitment to translating research-generated insights into advances that improve the human condition. Proven ability and interest in working as a member of a collaborative, multidisciplinary team. Demonstrable interpersonal and communication skills, including the ability to articulate a broad scientific vision to both scientists and non-scientists.     PNRI is committed to creating a diverse environment and all qualified candidates are encouraged to apply.     How to apply:   Want to be a part of the team PNRI?  Please apply today at: https://www.pnri.org/careers/staff-scientist-decoding-stress-project/   The annual base salary for this position is from $70,000 to $85,000 and the wage offered will be based on experience and qualifications.   PNRI requires vaccination for COVID 19 as a condition of employment.   Please see www.pnri.org for more information.   About PNRI :   PNRI is an independent, nonprofit, biomedical research institute with a distinguished history of contributing scientific advances to improve health. We believe genetic research holds untapped potential to improve human health. PNRI pursues an unanswered question in the field of genetics: what keeps people healthy in the face of genetic and environmental risk?  At PNRI, our culture encourages originality, risk-taking, and interdisciplinary collaboration.   PNRI is an equal opportunity employer.  PNRI does not, and will not, discriminate against any applicant or employee on the basis of race, creed, ancestry, color, religion, sex, gender, gender identity/expression, sexual orientation, national origin, citizenship status, mental or physical disability, age, genetic information, veteran status, marital or family status, family or medical care leave, pregnancy or related condition (including childbirth and/or nursing), political affiliation or any other characteristic protected by state or federal law or local ordinance.  We believe diversity, equity, inclusion, and belonging is not only good business, it’s the right thing to do.